https://www.zupyak.com/p/3570707/t/how-psychedelic-mushrooms-affect-the-brain How Psychedelic Mushrooms Affect The Brain? Psychedelic mushrooms, also known as magic mushrooms, have been used for centuries in various cultures for their mind-altering properties. These mushrooms contain a chemical compound called psilocybin, which is responsible for their psychedelic effects. Psilocybin affects the brain in a way that alters perception, mood, and consciousness. In this article, we will discuss how psychedelic mushrooms affect the brain, their potential to cure depression and treat PTSD, and the difference between psychedelic and psychoactive substances.